The mission of the Blaser Laboratory is to understand how the hematopoietic microenvironment regulates stem cell clonal diversity under conditions of stress. Exposure to cytotoxic compounds, either environmental toxins or cancer chemotherapy, puts stress on hematopoietic stem cells to regenerate mature blood cells. Stress hematopoiesis confers selective pressure on hematopoietic stem cells allowing outgrowth of the most resistant and highly proliferative clones. These features lead to the development of highly aggressive myeloid neoplasms that are difficult to treat and have extremely poor prognosis. The Blaser Lab is using the zebrafish to understand how the blood vessels, stromal cells and other components of the hematopoietic microenvironment interact with stem cells under conditions of stress. Finding ways to help the hematopoietic microenvironment support a more diverse population of stem cell clones may lead to new approaches to treat or even prevent these aggressive hematologic disorders.
The Blaser Lab and The Ohio State University Wexner Medical Center is a proud part of one of America’s largest and most comprehensive universities. On the university’s main Columbus campus, more than 56,000 students are able to choose from 14 colleges, 175 undergraduate majors and 240 master’s, doctoral and professional degree programs. Ohio State is consistently ranked as Ohio’s best and one of the nation’s top-20 public universities.
The Blaser Lab and the comprehensive cancer center promotes a strong culture of collaboration. Interprogrammatic collaborations, collaborations with researchers in these Ohio State colleges and collaborations with researchers at other cancer centers and institutions are encouraged. As a result, researchers can tackle complex and important questions that require broad, interdisciplinary expertise.
The Blaser Lab and Ohio State cancer researchers are working with graduate students, postdoctoral researchers and in some cases undergraduate students—to gain new knowledge about the causes, treatment, diagnosis and prevention of cancer. Our work ranges from basic molecular and cellular science to translational studies designed to find and bring new treatments quickly to patients, and to clinical trials that evaluate the safety and effectiveness of experimental treatments in patients. This research is reducing cancer incidence in human populations and improving the quality of life for cancer survivors.
The Ohio State University Comprehensive Cancer Center
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)–designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.
Cancer is no longer defined solely by stage and location, but rather by its biologic and genetic makeup. There is no routine cancer — it is different in each person. Working together and utilizing state-of-the-art facilities and technology, clinicians and researchers at Ohio State are speeding the development and delivery of treatments that target the molecules and markers fueling each person’s unique cancer.
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